There's no real cause for health alarms at the Masai Mara National Reserve, especially if you've taken care of the ever-present threat of malaria by taking prophylactics and following the recommendations - like wearing long-sleeved clothing after dark and applying insect repellent.
The water is safe to drink and there's a major hospital at Nairobi, 100km east of the park.
The Masai Mara National Reserve is a fairly safe place. That said, getting out of your vehicle in the game reserve is highly inadvisable and you should make sure you follow the instructions of your guide when out game viewing.
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